Calculating estimates for the amount of Gd that is permanently bound in the body, and cannot removed by chelation. Dr Semelka's opinions.

These are my estimates for the Gd retained in the body, with the final calculation of what is not susceptible to removal with chelation.

There are many unknowns, I present my estimates of these unknowns:

How much of the total of Gd deposits ends up in major organ cells- my opinion a small amount, < 5%.

How much Gd that are enveloped in lysosomes inside cells, gets discharged into the extracellular space - my opinion > 50%. This is then readily susceptible to direct chelation.

How much Gd in the cells in various locations are subject to le Chatelier's re-equilibration principle that then makes them exchangeable between intracellular and extracellular location. my opinion 30-40%.

Hope much of the  Gd that is in cells is permanently bound into cells and cannot experience chelation removal with DTPA during the cell's lifetime,  my opinion is 10%.

How many of these cells with permanent deposition of Gd have almost no turnover (eg: neurons), my opinion 1 % of the total permanent deposition cells.

If you add up all the totals of the above then permanent deposition of Gd in the body, that is not susceptible to removal with DTPA is about 1% of  5% of the 2 % (2% is  the amount of Gd retained at 1 year following linear GBCA administration) in the body that sticks there permanently despite DTPA chelation is about 0.001% of the GBCA administered.

Richard Semelka, MD